Mostafa Hosseini Selected Research

mannuronic acid

4/2022	A controlled, randomized phase II clinical trial for efficacy and safety evaluation of mannuronic acid in secondary progressive form of multiple sclerosis.
2/2022	Evaluating Mannuronic Acid Effect on Gene Expression Profile of Inflammatory Mediators in Rheumatoid Arthritis Patients.
10/2021	Evaluation of the Effect of Mannuronic Acid as a Novel NSAID With Immunosuppressive Properties on Expression of SOCS1, SOCS3, SHIP1, and TRAF6 Genes and Serum Levels of IL-6 and TNF-α in Patients With Multiple Sclerosis.
1/2021	Influence of β-D-mannuronic Acid, as a New Member of Non-steroidal Anti- Inflammatory Drugs Family, on the Expression Pattern of Chemokines and their Receptors in Rheumatoid Arthritis.
1/2020	The Situation of Chemokine Ligands and Receptors Gene Expression, Following the Oral Administration of Drug Mannuronic Acid in Rheumatoid Arthritis Patients.
10/2019	International multicenter randomized, placebo-controlled phase III clinical trial of β-D-mannuronic acid in rheumatoid arthritis patients.
1/2019	A randomized, controlled, phase II clinical trial of β-D-mannuronic acid (M2000) in pre-surgical breast cancer patients at early stage (T1-T2).
6/2018	A phase I/II randomized, controlled, clinical trial for assessment of the efficacy and safety of β-D-mannuronic acid in rheumatoid arthritis patients.
1/2018	Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial.

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Mostafa Hosseini Research Topics

Disease

13	Spinal Cord Injuries (Spinal Cord Injury) 08/2023 - 03/2016
8	Neoplasms (Cancer) 09/2023 - 07/2012
7	Infections 09/2020 - 09/2007
5	Rheumatoid Arthritis 02/2022 - 06/2018
5	Wounds and Injuries (Trauma) 03/2021 - 08/2009
4	Breast Neoplasms (Breast Cancer) 09/2023 - 07/2012
4	Neuralgia (Stump Neuralgia) 01/2022 - 09/2015
4	Pain (Aches) 01/2022 - 01/2014
4	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 01/2011
4	Lung Neoplasms (Lung Cancer) 01/2015 - 08/2009
3	COVID-19 09/2020 - 01/2020
3	Ankylosing Spondylitis 06/2019 - 01/2018
3	Hyperalgesia 10/2018 - 09/2015
3	Type 2 Diabetes Mellitus (MODY) 10/2005 - 06/2004
2	Hypertension (High Blood Pressure) 01/2023 - 01/2019
2	Multiple Sclerosis 04/2022 - 10/2021
2	Urinary Tract Infections (Urinary Tract Infection) 01/2022 - 01/2020
2	Obesity 01/2022 - 04/2020
2	Respiratory Tract Infections (Respiratory Tract Infection) 09/2020 - 08/2020
2	Inflammation (Inflammations) 09/2020 - 01/2018
2	Overweight 04/2020 - 09/2018
2	Craniocerebral Trauma (Head Injury) 08/2019 - 01/2019
2	Malnutrition (Nutritional Deficiencies) 01/2019 - 02/2015
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/2018 - 04/2018
2	Crush Syndrome 01/2017 - 06/2016
2	Cutaneous Leishmaniasis 10/2016 - 01/2007
2	Tuberculosis (Tuberculoses) 01/2016 - 01/2016
2	Opium Dependence 01/2013 - 08/2009
2	Peritonitis 09/2011 - 01/2010
2	Major Depressive Disorder (Major Depressive Disorders) 06/2010 - 03/2008
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2023
1	Stroke (Strokes) 02/2023
1	Weight Loss (Weight Reduction) 01/2022
1	Chronic Progressive Multiple Sclerosis 10/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2020
1	Infertility (Sterility) 10/2020
1	Pneumonia (Pneumonitis) 09/2020
1	Disease Progression 09/2020
1	Fever (Fevers) 09/2020
1	Human Influenza (Influenza) 09/2020
1	Coronavirus Infections 08/2020

Drug/Important Bio-Agent (IBA)

9	mannuronic acidIBA 04/2022 - 01/2018
8	Biomarkers (Surrogate Marker)IBA 09/2023 - 10/2012
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2013
4	VitaminsIBA 01/2020 - 06/2004
4	Therapeutic UsesIBA 01/2020 - 03/2008
3	Interleukin-6 (Interleukin 6)IBA 10/2021 - 06/2010
3	DNA (Deoxyribonucleic Acid)IBA 06/2019 - 12/2015
3	MineralsIBA 10/2005 - 06/2004
2	Peptides (Polypeptides)IBA 08/2023 - 04/2020
2	InterleukinsIBA 01/2022 - 01/2022
2	Serum AlbuminIBA 01/2022 - 01/2010
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/2021 - 09/2020
2	ChemokinesIBA 01/2021 - 01/2020
2	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 10/2020 - 05/2013
2	Naproxen (Naprosyn)FDA LinkGeneric 09/2020 - 01/2018
2	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2020 - 01/2017
2	AdiponectinIBA 04/2020 - 01/2019
2	LigandsIBA 01/2020 - 01/2016
2	Lipocalin-2IBA 01/2020 - 01/2018
2	CytokinesIBA 08/2019 - 06/2010
2	Cystatin CIBA 01/2018 - 01/2017
2	FluoridesIBA 05/2017 - 01/2016
2	Drinking WaterIBA 05/2017 - 01/2016
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 10/2016 - 01/2016
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 12/2015 - 01/2010
2	CholesterolIBA 01/2013 - 01/2010
2	CalciumIBA 01/2013 - 01/2010
2	OpiumIBA 01/2013 - 08/2009
2	Immunoglobulins (Immunoglobulin)IBA 09/2011 - 09/2007
2	Eicosapentaenoic AcidIBA 06/2010 - 03/2008
2	Fluoxetine (Prozac)FDA LinkGeneric 06/2010 - 03/2008
1	Tumor Biomarkers (Tumor Markers)IBA 09/2023
1	Epothilones (Epothilone)IBA 08/2023
1	Metformin (Glucophage)FDA LinkGeneric 02/2023
1	Hypoglycemic Agents (Hypoglycemics)IBA 02/2023
1	antiarrhythmic peptide (AAP)IBA 01/2023
1	Chondroitin ABC LyaseIBA 09/2022
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	gamma-Aminobutyric Acid (GABA)IBA 01/2022
1	TNF Receptor-Associated Factor 6 (TRAF6)IBA 10/2021
1	NexusIBA 03/2021
1	Myelin Basic ProteinIBA 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2020
1	Conditioned Culture MediaIBA 12/2020
1	CollagenIBA 12/2020
1	Oseltamivir (Tamiflu)FDA Link 09/2020
1	Acetaminophen (Paracetamol)FDA LinkGeneric 09/2020
1	Clarithromycin (Biaxin)FDA LinkGeneric 09/2020
1	Ibuprofen (Motrin)FDA LinkGeneric 09/2020

Therapy/Procedure

10	Therapeutics 01/2022 - 09/2015
7	Transplantation 12/2022 - 09/2015
3	Tattooing 06/2017 - 11/2009
3	Continuous Ambulatory Peritoneal Dialysis (CAPD) 05/2013 - 01/2010
2	Oral Administration 01/2020 - 10/2019
2	Aftercare (After-Treatment) 01/2019 - 10/2016
2	Peritoneal Dialysis 11/2017 - 05/2013
2	Drug Therapy (Chemotherapy) 07/2012 - 01/2011
1	Bariatric Surgery 01/2022
1	Duration of Therapy 09/2020